The controversy continues: Does antidepressant use affect suicidality in depressed children and adolescents, and if so, in which direction? In 2003, researchers reported an association between increased use of antidepressants and decreased suicide in adolescents (Journal Watch Psychiatry Dec 2004, p. 93, and Archives of General Psychiatry 2003; 60:978). To learn more, the same research group examined data among all Medicaid patients, ages 6 to 64, hospitalized for depression during a 2-year period (1999-2000).
This is a study by Kiki Chang, M.D., et al which discusses the amygdala's prominent role in emotion processing and response.The amygdala was found to be smaller in BD adolescents, and larger in adults taking lithium.
An errant enzyme linked to bipolar disorder, in the brain’s prefrontal cortex, impairs cognition under stress, an animal study shows. The disturbed thinking, impaired judgment, impulsivity, and distractibility seen in mania, a destructive phase of bipolar disorder, may be traceable to overactivity of protein kinase C (PKC), suggests the study, funded by the National Institutes of Health’s (NIH) National Institute of Mental Health (NIMH) and National Institute on Aging (NIA), and the Stanley Foundation. It explains how even mild stress can worsen cognitive symptoms, as occurs in bipolar disorder, which affects 2 million Americans.